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Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice

Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS animal models. The umbilical cord (UC) is a source of highly proliferating fetal MSCs, more easily collectable than othe...

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Principais autores: Francesca Sironi, Antonio Vallarola, Martina Bruna Violatto, Laura Talamini, Mattia Freschi, Roberta De Gioia, Chiara Capelli, Azzurra Agostini, Davide Moscatelli, Massimo Tortarolo, Paolo Bigini, Martino Introna, Caterina Bendotti
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-12-01
Serier:Stem Cell Research
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Amyotrophic lateral sclerosis
Mesenchymal stem cells
Umbilical cord
Transgenic SOD1G93A mice
Motor neuron
Gliosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S1873506117302350
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