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A yeast surface display platform for characterizing CAR T cell responses to cancer antigens

Abstract Chimeric antigen receptor (CAR) T cells have become an established immunotherapy with promising results for the treatment of hematological malignancies. However, modulation of the targeted antigen’s surface level in cancer cells affects the quality and safety of CAR-T cell therapy. Here we...

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Detalles Bibliográficos
Principais autores: Marcus Deichmann, Giovanni Schiesaro, Keerthana Ramanathan, Katrine Zeeberg, Nanna M. T. Koefoed, Maria Ormhøj, Rasmus U. W. Friis, Ryan T. Gill, Sine R. Hadrup, Emil D. Jensen, Michael K. Jensen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-11-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-025-65236-7
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