CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells
Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory domain to augment activation. While therapy with s...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2023-01-01
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| Schriftenreihe: | Frontiers in Immunology |
| Schlagworte: | |
| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1090959/full |
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