Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter

Most therapeutic monoclonal antibodies in biopharmaceutical processes are produced in Chinese hamster ovary (CHO) cells. Technological advances have rendered the selection procedure for higher producers a robust protocol. However, information on molecular mechanisms that impart the property of hyper...

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Detalhes bibliográficos

Principais autores:	Hussain Dahodwala, Prashant Kaushik, Vijay Tejwani, Chih-Chung Kuo, Patrice Menard, Michael Henry, Bjorn G. Voldborg, Nathan E. Lewis, Paula Meleady, Susan T. Sharfstein
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2019-11-01
Colecção:	Current Research in Biotechnology
Assuntos:	Chromatin immunoprecipitation (ChIP) CHO cell line selection Nuclear proteomics Transcriptional regulation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2590262819300061
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