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SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells

Abstract Sodium butyrate (NaBu), well-known as a histone deacetylase inhibitor and for its capacity to impede cell growth, can enhance the production of a specific protein, such as an antibody, in recombinant Chinese hamster ovary (CHO) cell cultures. In this study, two CHO cell lines, namely K1 and...

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Principais autores: Mauro Galli, Lillian Chia-Yi Liu, Kae Hwan Sim, Yee Jiun Kok, Katherine Wongtrakul-Kish, Terry Nguyen-Khuong, Stephen Tate, Xuezhi Bi
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2024-12-01
Serier:AMB Express
Fag:
Butyric acid
CHO cells
SWATH-MS
Redox
mAbs
Online adgang:https://doi.org/10.1186/s13568-024-01807-z
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