Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Metabolic flexibility, the capacity to adapt fuel utilization in response to nutrient availability, is essential for maintaining energy homeostasis and preventing metabolic disease. Here, we investigate the role of Ulk1 phosphorylation at serine 555 (S555), a site regulated by AMPK, in coordinating...

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主要な著者:	Orion S. Willoughby, Anna S. Nichenko, Matthew H. Brisendine, Niloufar Amiri, Shelby N. Henry, Daniel S. Braxton, John R. Brown, Braeden J. Kraft, Kalyn S. Jenkins, Adele K. Addington, Alexey V. Zaitsev, Steven T. Burrows, Ryan P. McMillan, Haiyan Zhang, Spencer A. Tye, Charles P. Najt, Siobhan E. Craige, Timothy W. Rhoads, Junco S. Warren, Joshua C. Drake
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-01-01
シリーズ:	Molecular Metabolism
主題:	Ulk1 Glucose Amino acids Mitochondria Metabolic flexibility
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2212877825001954
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