Antibody‐Oligonucleotide Conjugates Reduce Trim63 Expression in Skeletal Muscle and Prevent Muscle Atrophy

ABSTRACT Background Muscle atrophy is associated with many disease states and can become a debilitating and life‐threatening condition with few or no therapeutic options. The muscle‐specific E3 ligase muscle RING‐finger protein‐1 (TRIM63/MuRF1) has been identified as a promising target to treat musc...

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Үндсэн зохиолчид:	Michael Hood, Beatrice Darimont, Maria Azzurra Missinato, Matthew Diaz, Kellie Lemoine, Yunyu Shi, Danny Arias, Christopher D. Miller, Arvind Bhattacharya, Maryam Jordan, Gulin Erdogan, Michael Cochran, Hae Won Kwon, Michael Moon, Yanling Chen, Andrew Geall, Venkata Ramana Doppalapudi, Rob Burke, Arthur A. Levin, Hanhua Huang, Barbora Malecova
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2026-01-01
Цуврал:	JCSM Communications
Нөхцлүүд:	antibody‐oligonucleotide conjugate CD71 MuRF1/TRIM63 muscle atrophy RNA interference skeletal muscle
Онлайн хандалт:	https://doi.org/10.1002/rco2.70035
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!