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Antibody‐Oligonucleotide Conjugates Reduce Trim63 Expression in Skeletal Muscle and Prevent Muscle Atrophy

ABSTRACT Background Muscle atrophy is associated with many disease states and can become a debilitating and life‐threatening condition with few or no therapeutic options. The muscle‐specific E3 ligase muscle RING‐finger protein‐1 (TRIM63/MuRF1) has been identified as a promising target to treat musc...

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Principais autores: Michael Hood, Beatrice Darimont, Maria Azzurra Missinato, Matthew Diaz, Kellie Lemoine, Yunyu Shi, Danny Arias, Christopher D. Miller, Arvind Bhattacharya, Maryam Jordan, Gulin Erdogan, Michael Cochran, Hae Won Kwon, Michael Moon, Yanling Chen, Andrew Geall, Venkata Ramana Doppalapudi, Rob Burke, Arthur A. Levin, Hanhua Huang, Barbora Malecova
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:JCSM Communications
Fag:
antibody‐oligonucleotide conjugate
CD71
MuRF1/TRIM63
muscle atrophy
RNA interference
skeletal muscle
Online adgang:https://doi.org/10.1002/rco2.70035
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