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Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets.

Current work in elucidating relationships between diseases has largely been based on pre-existing knowledge of disease genes. Consequently, these studies are limited in their discovery of new and unknown disease relationships. We present the first quantitative framework to compare and contrast disea...

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Detalhes bibliográficos
Main Authors: Silpa Suthram, Joel T Dudley, Annie P Chiang, Rong Chen, Trevor J Hastie, Atul J Butte
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-02-01
Colecção:PLoS Computational Biology
Acesso em linha:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000662&type=printable
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