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Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets.

Current work in elucidating relationships between diseases has largely been based on pre-existing knowledge of disease genes. Consequently, these studies are limited in their discovery of new and unknown disease relationships. We present the first quantitative framework to compare and contrast disea...

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Autori principali: Silpa Suthram, Joel T Dudley, Annie P Chiang, Rong Chen, Trevor J Hastie, Atul J Butte
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2010-02-01
Serie:PLoS Computational Biology
Accesso online:http://europepmc.org/articles/PMC2816673?pdf=render
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