Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...

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Autors principals:	Sabrina Reinehr, Sara C. Gomes, Caroline J. Gassel, M. Ali Asaad, Gesa Stute, Marc Schargus, H. Burkhard Dick, Stephanie C. Joachim
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-12-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	glaucoma complement complement inhibition membrane attack complex optical coherence tomography
Accés en línia:	https://www.frontiersin.org/article/10.3389/fphar.2019.01381/full
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