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Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...

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Principais autores: Sabrina Reinehr, Sara C. Gomes, Caroline J. Gassel, M. Ali Asaad, Gesa Stute, Marc Schargus, H. Burkhard Dick, Stephanie C. Joachim
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-12-01
Serier:Frontiers in Pharmacology
Fag:
glaucoma
complement
complement inhibition
membrane attack complex
optical coherence tomography
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2019.01381/full
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