Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the thera...

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Principais autores:	Sabrina Reinehr, Sara C. Gomes, Caroline J. Gassel, M. Ali Asaad, Gesa Stute, Marc Schargus, H. Burkhard Dick, Stephanie C. Joachim
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-12-01
Series:	Frontiers in Pharmacology
Assuntos:	glaucoma complement complement inhibition membrane attack complex optical coherence tomography
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fphar.2019.01381/full
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