Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells

Natural killer (NK) cells have the intrinsic ability to kill cancer cells and are thus targeted in immunotherapy. Anti-CD19 CAR NK cells have shown efficacy in clinical studies in treating B cell malignancies; however, the full cytotoxic capacities of CAR NK cells may be limited by the expression of...

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Autors principals:	Juliane Mietz, Lukas Egli, Meike Misiune, Arianna Picozzi, Nicolò Coianiz, Danielle Thompson, Marianna Ponzo, Alisson Charmey, Beat Bornhauser, Chiara F. Magnani, Christian Münz, Obinna Chijioke
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-03-01
Col·lecció:	Molecular Therapy: Oncology
Matèries:	MT: Regular Issue B cell malignancies cancer immunotherapy CAR NK cells CRISPR-Cas9 NKG2A editing
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2950329926000020
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