The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice

Increasing evidence indicates that a key factor in neurodegenerative diseases is the activation of the unfolded protein response (UPR) caused by an accumulation of misfolded proteins in the endoplasmic reticulum (ER stress). Particularly, in Huntington's disease (HD) mutant huntingtin (mHtt) toxicit...

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מידע ביבליוגרפי

Principais autores:	Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2023-08-01
סדרה:	Neurobiology of Disease
נושאים:	Huntington's disease hippocampus ER stress Memory PERK Therapeutics
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S0969996123002401
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