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The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice

Increasing evidence indicates that a key factor in neurodegenerative diseases is the activation of the unfolded protein response (UPR) caused by an accumulation of misfolded proteins in the endoplasmic reticulum (ER stress). Particularly, in Huntington's disease (HD) mutant huntingtin (mHtt) toxicit...

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Gardado en:
Principais autores: Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2023-08-01
Series:Neurobiology of Disease
Assuntos:
Huntington's disease
hippocampus
ER stress
Memory
PERK
Therapeutics
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S0969996123002401
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