Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis

Abstract Background Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titres in Bacillus subtilis. Synthetic biology provides a rational engineering principle for the transcriptional optimisation of key enzymes and the arti...

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Главные авторы:	Xiumin Ding, Zhiming Zheng, Genhai Zhao, Li Wang, Han Wang, Qiang Yang, Mengxue Zhang, Luyao Li, Peng Wang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2022-05-01
Серии:	Microbial Cell Factories
Предметы:	Menaquinone-7 Bacillus subtilis Synthetic biology Metabolic engineering Cofactor engineering NADH kinase
Online-ссылка:	https://doi.org/10.1186/s12934-022-01823-3
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