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Bottom-up synthetic biology approach for improving the efficiency of menaquinone-7 synthesis in Bacillus subtilis

Abstract Background Menaquinone-7 (MK-7), which is associated with complex and tightly regulated pathways and redox imbalances, is produced at low titres in Bacillus subtilis. Synthetic biology provides a rational engineering principle for the transcriptional optimisation of key enzymes and the arti...

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Autori principali: Xiumin Ding, Zhiming Zheng, Genhai Zhao, Li Wang, Han Wang, Qiang Yang, Mengxue Zhang, Luyao Li, Peng Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-05-01
Serie:Microbial Cell Factories
Soggetti:
Menaquinone-7
Bacillus subtilis
Synthetic biology
Metabolic engineering
Cofactor engineering
NADH kinase
Accesso online:https://doi.org/10.1186/s12934-022-01823-3
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