Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia

Abstract Background The enzyme farnesyl diphosphate synthase (FPPS) is positioned in the intersection of different sterol biosynthesis pathways such as those producing isoprenoids, dolichols and ergosterol. FPPS is ubiquitous in eukaryotes and is inhibited by nitrogen-containing bisphosphonates (N-B...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Ana Paula R. Gadelha, Claudia Maia Brigagao, Martha Barros da Silva, Aline Beatriz Mello Rodrigues, Ana Carolina Ramos Guimarães, Fernando Paiva, Wanderley de Souza, Cristina Henriques
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2020-04-01
Ráidu:	Parasites & Vectors
Fáttát:	Bisphosphonates Farnesyl diphosphate synthase FPPS Leishmania Giardia Protozoan
Liŋkkat:	http://link.springer.com/article/10.1186/s13071-020-04019-z
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!