Predicting substrates for orphan solute carrier proteins using multi-omics datasets

Abstract Solute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC proteins are ‘orphans’ whose substra...

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Autors principals:	Y. Zhang, S. Newstead, P. Sarkies
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-02-01
Col·lecció:	BMC Genomics
Matèries:	Membrane Transport Solute Carrier Proteins Deorphanization Computational Biology Gene expression Metabolomics
Accés en línia:	https://doi.org/10.1186/s12864-025-11330-5
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