Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1

Creatine serves as an ATP buffer and is thus an integral component of cellular energy metabolism. Most cells maintain their creatine levels via uptake by the creatine transporter (CRT-1, SLC6A8). The activity of CRT-1, therefore, is a major determinant of cytosolic creatine concentrations. We determ...

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Hlavní autoři:	Clemens V. Farr, Ali El-Kasaby, Fatma A. Erdem, Sonja Sucic, Michael Freissmuth, Walter Sandtner
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-06-01
Edice:	Frontiers in Physiology
Témata:	creatine creatine transporter-1 solute carrier 6/SLC6 concentrative power cooperative binding kinetic modeling
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphys.2022.919439/full
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