Delayed and accelerated aging share common longevity assurance mechanisms.

Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wi...

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Manylion Llyfryddiaeth

Prif Awduron:	Björn Schumacher, Ingrid van der Pluijm, Michael J Moorhouse, Theodore Kosteas, Andria Rasile Robinson, Yousin Suh, Timo M Breit, Harry van Steeg, Laura J Niedernhofer, Wilfred van Ijcken, Andrzej Bartke, Stephen R Spindler, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, George A Garinis
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Public Library of Science (PLoS) 2008-08-01
Cyfres:	PLoS Genetics
Mynediad Ar-lein:	http://europepmc.org/articles/PMC2493043?pdf=render
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