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The Study of Alternative Splicing Events in Human Induced Pluripotent Stem Cells From a Down's Syndrome Patient

Down's syndrome (DS) is one of the most commonly known disorders with multiple congenital disabilities. Besides severe cognitive impairment and intellectual disability, individuals with DS also exhibit additional phenotypes of variable penetrance and severity, with one or more comorbid conditions, i...

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Principais autores: Yunjie Wang, Zexu Li, Guanheng Yang, Linlin Cai, Fan Yang, Yaqiong Zhang, Yitao Zeng, Qingwen Ma, Fanyi Zeng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-09-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
Down's syndrome
alternative splicing
iPSCs
gene regulation
differentially expressed genes
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2021.661381/full
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