RNA-guided single/double gene repressions in Corynebacterium glutamicum using an efficient CRISPR interference and its application to industrial strain

Abstract Background The construction of microbial cell factories requires cost-effective and rapid strain development through metabolic engineering. Recently, RNA-guided CRISPR technologies have been developed for metabolic engineering of industrially-relevant host. Results To demonstrate the applic...

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Автори:	Jaehyun Park, Hyojung Shin, Sun-Mi Lee, Youngsoon Um, Han Min Woo
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2018-01-01
Серія:	Microbial Cell Factories
Предмети:	Metabolic engineering Synthetic biology CRISPR interference Corynebacterium glutamicum
Онлайн доступ:	http://link.springer.com/article/10.1186/s12934-017-0843-1
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