Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Abstract Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have...

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Bibliografski detalji

Glavni autori:	Md Soriful Islam, Sadia Afrin, Bhuchitra Singh, Friederike L. Jayes, Joshua T. Brennan, Mostafa A. Borahay, Phyllis C. Leppert, James H. Segars
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2021-07-01
Serija:	Clinical and Translational Medicine
Teme:	collagenase extracellular matrix Hippo signaling nintedanib uterine fibroids verteporfin
Online pristup:	https://doi.org/10.1002/ctm2.475
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