Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction

Abstract Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes. In breast cancer, increased tumor stiffness is associated with elevated metastasis risks and poor survival. Here we report a unique role of the JAK family kinase TYK2 in suppressing breast cancer metast...

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Autors principals:	Zhimin Hu, Hannah E. Majeski, Aida Mestre-Farrera, Shirong Cai, Arya Lalezarzadeh, Yichi Zhang, Kei-Ichiro Arimoto, Dong-Er Zhang, Helen Piwnica-Worms, Laurent Fattet, Jing Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-03-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-70518-9
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