Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction
Abstract Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes. In breast cancer, increased tumor stiffness is associated with elevated metastasis risks and poor survival. Here we report a unique role of the JAK family kinase TYK2 in suppressing breast cancer metast...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2026-03-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-026-70518-9 |
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