Design, Synthesis and In Vitro Antimicrobial Activity of 6-(1<i>H</i>-Benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-thio-3,4-dihydrothieno[2,3-<i>d</i>]pyrimidines

The rapid development in bacterial resistance to many groups of known antibiotics forces the researchers to discover antibacterial drug candidates with previously unknown mechanisms of action, one of the most relevant being the inhibition of tRNA (Guanine37-N1)-methyltransferase (TrmD). The discover...

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Detalhes bibliográficos

Principais autores:	Sergiy V. Vlasov, Olena D. Vlasova, Hanna I. Severina, Konstantin Yu. Krolenko, Oleksandr V. Borysov, Amjad Ibrahim M. Abu Sharkh, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-11-01
coleção:	Scientia Pharmaceutica
Assuntos:	thieno[2,3-<i>d</i>]pyrimidine antimicrobial activity TrmD inhibitor docking study <i>Pseudomonas aeruginosa</i>
Acesso em linha:	https://www.mdpi.com/2218-0532/89/4/49
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