Design, Synthesis and In Vitro Antimicrobial Activity of 6-(1<i>H</i>-Benzimidazol-2-yl)-3,5-dimethyl-4-oxo-2-thio-3,4-dihydrothieno[2,3-<i>d</i>]pyrimidines

The rapid development in bacterial resistance to many groups of known antibiotics forces the researchers to discover antibacterial drug candidates with previously unknown mechanisms of action, one of the most relevant being the inhibition of tRNA (Guanine37-N1)-methyltransferase (TrmD). The discover...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sergiy V. Vlasov, Olena D. Vlasova, Hanna I. Severina, Konstantin Yu. Krolenko, Oleksandr V. Borysov, Amjad Ibrahim M. Abu Sharkh, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-11-01
Schriftenreihe:	Scientia Pharmaceutica
Schlagworte:	thieno[2,3-<i>d</i>]pyrimidine antimicrobial activity TrmD inhibitor docking study <i>Pseudomonas aeruginosa</i>
Online-Zugang:	https://www.mdpi.com/2218-0532/89/4/49
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!