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Caloric restriction enhances inheritance of wild-type mitochondrial DNA in Saccharomyces cerevisiae

Abstract In Saccharomyces cerevisiae, an asymmetrical division model, mitochondrial (mt) DNA typically exists in a homoplasmic state, but mutations frequently occur. Rolling-circle replication, mediated by the mtDNA recombinase Mhr1p, forms tandem concatemers that are selectively transmitted to budd...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Wenjuan Zhu, Minoru Yoshida, Feng Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-11-01
Schriftenreihe:Scientific Reports
Schlagworte:
Online-Zugang:https://doi.org/10.1038/s41598-025-23888-x
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