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Caloric restriction enhances inheritance of wild-type mitochondrial DNA in Saccharomyces cerevisiae

Abstract In Saccharomyces cerevisiae, an asymmetrical division model, mitochondrial (mt) DNA typically exists in a homoplasmic state, but mutations frequently occur. Rolling-circle replication, mediated by the mtDNA recombinase Mhr1p, forms tandem concatemers that are selectively transmitted to budd...

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Principais autores: Wenjuan Zhu, Minoru Yoshida, Feng Ling
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-11-01
Serier:Scientific Reports
Fag:
Mitochondria
mtDNA
Homoplasmy
Heteroplasmy
Preselection
Hypersuppresiveness
Online adgang:https://doi.org/10.1038/s41598-025-23888-x
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