MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect

Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single experiment. Despite the importance of MAVE data for basic and clinical research, there is no standard resource for their discover...

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Autores principales:	Daniel Esposito, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P. Roth, Douglas M. Fowler, Alan F. Rubin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-11-01
Colección:	Genome Biology
Materias:	Deep mutational scanning Massively parallel reporter assays Large-scale mutagenesis MAVE Multiplexed assay of variant effect Genome interpretation
Acceso en línea:	http://link.springer.com/article/10.1186/s13059-019-1845-6
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