Effect of microbubble-assisted gemcitabine delivery with repeated ultrasound exposure in a pancreatic cancer organ-on-a-chip model
Abstract The fibrotic stroma of solid tumours poses a physical barrier to drug delivery and effective treatment. Interaction between cancerous epithelial cells and their surrounding stromal partners results in the development of a rigid, collagenous matrix environment with reduced interstitial flow,...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2025-12-01
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| coleção: | Scientific Reports |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1038/s41598-025-30612-2 |
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