The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furtherm...

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Bibliografiske detaljer

Principais autores:	Yang Wu, Chun Zhang, Kuirong Jiang, Jens Werner, Alexandr V. Bazhin, Jan G. D’Haese
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-01-01
Serier:	Frontiers in Oncology
Fag:	pancreatic stellate cells pancreatic ductal adenocarcinoma tumor microenvironment stroma-targeting strategy tumor therapy
Online adgang:	https://www.frontiersin.org/articles/10.3389/fonc.2020.621937/full
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