Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome

Abstract Murine models of Alzheimer’s disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. Here we present the comprehensive, age-dependent brain proteome and phosphoproteome across multiple mouse models of amyloidosis. We...

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Autores principales:	Jay M. Yarbro, Xian Han, Abhijit Dasgupta, Ka Yang, Danting Liu, Him K. Shrestha, Masihuz Zaman, Zhen Wang, Kaiwen Yu, Dong Geun Lee, David Vanderwall, Mingming Niu, Huan Sun, Boer Xie, Ping-Chung Chen, Yun Jiao, Xue Zhang, Zhiping Wu, Surendhar R. Chepyala, Yingxue Fu, Yuxin Li, Zuo-Fei Yuan, Xusheng Wang, Suresh Poudel, Barbora Vagnerova, Qianying He, Andrew Tang, Patrick T. Ronaldson, Rui Chang, Gang Yu, Yansheng Liu, Junmin Peng
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-02-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-56853-3
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