Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice

IntroductionVisual dysfunction and retinal structural changes can occur early in Alzheimer's disease (AD), but the molecular basis of these early alterations remains unclear.MethodsWe performed quantitative proteomic profiling of the retina and brain from 4-week-old triple-transgenic AD (3xTg-AD) mi...

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Principais autores:	Artjola Puja, Rachel McNeel, Rong Xu, Siyan Zhu, David Hansman, Jianhai Du
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	alzheimer’s disease brain mitochondria neurodegenerative disorders proteomics retina
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1827348/full
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