PcG proteins, DNA methylation, and gene repression by chromatin looping.

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream ( approximately 30 kb) of and extending approximately 60 kb around one such gene, GATA-4, is organized-in Tera-2 undifferenti...

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Bibliografiske detaljer

Principais autores:	Vijay K Tiwari, Kelly M McGarvey, Julien D F Licchesi, Joyce E Ohm, James G Herman, Dirk Schübeler, Stephen B Baylin
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2008-12-01
Serier:	PLoS Biology
Online adgang:	http://europepmc.org/articles/PMC2592355?pdf=render
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