PcG proteins, DNA methylation, and gene repression by chromatin looping.

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream ( approximately 30 kb) of and extending approximately 60 kb around one such gene, GATA-4, is organized-in Tera-2 undifferenti...

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主要な著者:	Vijay K Tiwari, Kelly M McGarvey, Julien D F Licchesi, Joyce E Ohm, James G Herman, Dirk Schübeler, Stephen B Baylin
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2008-12-01
シリーズ:	PLoS Biology
オンライン･アクセス:	http://europepmc.org/articles/PMC2592355?pdf=render
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