PcG proteins, DNA methylation, and gene repression by chromatin looping.
Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream ( approximately 30 kb) of and extending approximately 60 kb around one such gene, GATA-4, is organized-in Tera-2 undifferenti...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2008-12-01
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| Серии: | PLoS Biology |
| Online-ссылка: | http://europepmc.org/articles/PMC2592355?pdf=render |
| Метки: |
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