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The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

Abstract Background Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacuoles derived from macropinosomes and late endosomes, followed by metabo...

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Autori principali: Zehui Li, Nneka E. Mbah, Jean H. Overmeyer, Jeffrey G. Sarver, Sage George, Christopher J. Trabbic, Paul W. Erhardt, William A. Maltese
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-01-01
Serie:BMC Cancer
Soggetti:
Glioblastoma
Methuosis
Cell death
Chalcones
C-Jun N-terminal kinase
Vacuoles
Accesso online:http://link.springer.com/article/10.1186/s12885-019-5288-y
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