HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells

Abstract The metastasis and chemotherapy resistance of gastric cancer significantly contribute to treatment failure and mortality. Based on previous studies, we hypothesized that Heat Shock Protein 90 (HSP90) interacts with and upregulates Pseudouridine Synthase 7 (PUS7), which in turn promotes THUM...

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Hlavní autoři:	Ziwei Ye, Junjie He, Renjie Zuo, Chenchun Ding, Zhenzhen Guo, Quan Liao, Xuan Zhu, Guoyan Liu, Li Lin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-10-01
Edice:	Scientific Reports
Témata:	Gastric cancer Mechanism HSP90 PUS7 THUMPD1
On-line přístup:	https://doi.org/10.1038/s41598-025-20167-7
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