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HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells

Abstract The metastasis and chemotherapy resistance of gastric cancer significantly contribute to treatment failure and mortality. Based on previous studies, we hypothesized that Heat Shock Protein 90 (HSP90) interacts with and upregulates Pseudouridine Synthase 7 (PUS7), which in turn promotes THUM...

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Auteurs principaux: Ziwei Ye, Junjie He, Renjie Zuo, Chenchun Ding, Zhenzhen Guo, Quan Liao, Xuan Zhu, Guoyan Liu, Li Lin
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2025-10-01
Collection:Scientific Reports
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Accès en ligne:https://doi.org/10.1038/s41598-025-20167-7
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