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Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1

Abstract Background Bladder cancer is a urological carcinoma with high incidence, among which muscle invasive bladder cancer (MIBC) is a malignant carcinoma with high mortality. There is an urgent need to develop new drugs with low toxicity and high efficiency for MIBC because existing medication ha...

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Main Authors: Ruijiao Chen, Xiaopeng Hao, Jingyuan Chen, Changyue Zhang, Huixia Fan, Fuming Lian, Xiaochuan Chen, Chao Wang, Yong Xia
Format: Artigo
Language:Inglês
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Jorunnamycin A
Muscle invasive bladder cancer
Proteomics
Transcriptomics
Proliferation
Apoptosis
Online Access:https://doi.org/10.1186/s12967-023-04400-3
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