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Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Niemann-Pick type C (NPC) disease, sometimes called childhood Alzheimer’s, is a rare neurovisceral lipid storage disease with progressive neurodegeneration leading to premature death. The disease is caused by loss-of-function mutations in the Npc1 or Npc2 gene which both result into lipid accumulati...

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Principais autores: Lien Van Hoecke, Caroline Van Cauwenberghe, Kristina Dominko, Griet Van Imschoot, Elien Van Wonterghem, Jonas Castelein, Junhua Xie, Wouter Claeys, Charysse Vandendriessche, Anna Kremer, Peter Borghgraef, Riet De Rycke, Silva Hecimovic, Roosmarijn E. Vandenbroucke
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-10-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
Niemann-Pick type C disease
choroid plexus
extracellular vesicles
blood-CSF-barrier
autophagosomes
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fncel.2021.757482/full
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