Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

Abstract Background Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body’s endogenous cholesterol...

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Үндсэн зохиолчид:	Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2019-11-01
Цуврал:	BMC Medicine
Нөхцлүүд:	Niemann–Pick C NPC1 HDL SRS Niemann–Pick A
Онлайн хандалт:	http://link.springer.com/article/10.1186/s12916-019-1423-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!