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Improving TCR Gene Therapy for Treatment of Haematological Malignancies

Adoptive immunotherapy using TCR gene modified T cells may allow separation of beneficial Graft versus tumour responses from harmful GvHD. Improvements to this include methods to generate high avidity or high affinity TCR, improvements in vector design and reduction in mispairing. Following adoptive...

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Autors principals: Emma Nicholson, Sara Ghorashian, Hans Stauss
Format: Artigo
Idioma:Inglês
Publicat: Wiley 2012-01-01
Col·lecció:Advances in Hematology
Accés en línia:http://dx.doi.org/10.1155/2012/404081
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