PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation

Abstract PARP1 detection of DNA strand breaks allosterically leads to PARP1 synthesis of poly(ADP-ribose) modifications that signal DNA damage. HPF1 engages activated PARP1 to control modification site selection. Understanding of the mechanism of DNA break detection and catalytic activation is incom...

Descripción completa

Detalles Bibliográficos

Autores principales:	Aleksandr Sverzhinsky, Huijun Xue, Marie-France Langelier, Marcelo V. Muniz Corrêa, Joshua Del Mundo, Scott Classen, Michal Hammel, Eli Rothenberg, John M. Pascal
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-69375-3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!