Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Abstract ADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A virus infection causing a rapid and...

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Egile Nagusiak:	Zhenyu Zhang, Isabel Uribe, Kaitlin A. Davis, Robert L. McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M. Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, Jens H. Kuhn, Anthony K. L. Leung, Andrew Mehle
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-12-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-025-66136-6
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

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