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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Abstract ADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A virus infection causing a rapid and...

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Autores principales: Zhenyu Zhang, Isabel Uribe, Kaitlin A. Davis, Robert L. McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M. Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, Jens H. Kuhn, Anthony K. L. Leung, Andrew Mehle
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2025-12-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-025-66136-6
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