PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation

Abstract PARP1 detection of DNA strand breaks allosterically leads to PARP1 synthesis of poly(ADP-ribose) modifications that signal DNA damage. HPF1 engages activated PARP1 to control modification site selection. Understanding of the mechanism of DNA break detection and catalytic activation is incom...

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Bibliografische Detailangaben

Hauptverfasser:	Aleksandr Sverzhinsky, Huijun Xue, Marie-France Langelier, Marcelo V. Muniz Corrêa, Joshua Del Mundo, Scott Classen, Michal Hammel, Eli Rothenberg, John M. Pascal
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-02-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-026-69375-3
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